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doi: 10.1186/s12883-017-1001-4 62

At the signaling level, the cascade initiated by ipamorelin binding to GHS-R1a involves phospholipase C activation and inositol trisphosphate (IP3) generation, leading to calcium release from intracellular stores a pathway distinct from the GHRH receptor, which primarily signals through cyclic AMP

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Removal of the dysfunctional proteins, organelles, and cells is necessary for preserving cellular homeostasis, and this is achieved by the processes of autophagy and programmed cell death, including apoptosis